What makes this individual's karyotype not normal? missing autosome An extra sex chromosome An extra autosome A missing sex chromosome

## Step 1A karyotype is a visual representation of the number and appearance of chromosomes in a cell. In a normal human karyotype, there are 46 chromosomes, including 44 autosomes and 2 sex chromosomes. ## Step 2The question asks us to identify what makes an individual's karyotype not normal. The options provided are:- Missing autosome- An extra sex chromosome- An extra autosome- A missing sex chromosome## Step 3We need to evaluate each option based on the definition of a normal karyotype.## Step 4Option A, "Missing autosome", would result in a karyotype with 45 chromosomes, which is a condition known as monosomy. This is a deviation from the normal karyotype and is therefore not normal.## Step 5Option B, "An extra sex chromosome", would result in a karyotype with 47 chromosomes, which is a condition known as trisomy. This is also a deviation from the normal karyotype and is therefore not normal.## Step 6Option C, "An extra autosome", would result in a karyotype with 47 chromosomes, which is a condition known as tetrasomy. This is also a deviation from the normal karyotype and is therefore not normal.## Step 7Option D, "A missing sex chromosome", would result in a karyotype with 45 chromosomes, which is a condition known as monosomy. This is also a deviation from the normal karyotype and is therefore not normal.